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Gene Therapy Controls HIV Longer Than Four Months in Study

8 years ago NAPWHA Gene Therapy

Sangamo Biosciences’ efforts to develop genetic therapies for HIV have had some early success, with two of three participants in one cohort maintaining control of the virus for an extended period during which they were not taking standard antiretroviral (ARV) treatment. The biotech company is conducting a Phase I/II study, known as SB-728-1101, of its…

Trust crucial to treatment interruption

At the Australasian HIV/AIDS Conference, Dr Gordon Campbell discussed participant motivations and experiences from an HIV cure clinical trial with treatment interruption (ATI). Dr Campbell interviewed participants from the TITAN study.  All were satisfied with their experience and most felt well during the study. Trust in the clinical research team was crucial to their participation and peace-of-mind. They would participate in future ATI trials. Support for the HIV community was a primary reason for participation. Other motivations were an interest in cure science, curiosity about their immune system, and optimism for improved treatment or cure.
These findings show that ATI trials can proceed with HIV community support and will guide future ATI trials.

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Gene therapy advance in mice

New sequencing method shows many blood-derived HIV particles are defective

High CD4 count before HIV treatment contributes to smaller HIV reservoir on ART

Vitamin D3 affects the HIV reservoir in humans

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Supported by the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health under Award Number U19AI096109. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

About NAPWHA

Founded in 1989, The National Association of People with HIV Australia (NAPWHA) is Australia’s peak non-government organisation representing community-based groups of people living with HIV (PLHIV).
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