New clue about HIV latency maintenance
Yale researchers have highlighted the role of APOBEC3A (A3A) in sustaining HIV latency. A3A is typically found in immune cells
Research spotlight
What should a functional cure for HIV aim to do?
What might a functional cure for HIV look like? In a recent study, researchers assumed that HIV reactivation from latency
Combination strategy delays virus rebound in monkeys
Harvard researchers have published exciting results on a combination approach to tackling latent HIV. In a monkey model of HIV
New light on tricky HIV structure
New details have emerged of the exact structure of an important HIV vaccine target. The membrane-proximal external region (MPER) is
Immune profiling tool to identify exhausted cells
T cell exhaustion is a type of immune dysfunction that occurs in cancer and chronic infections. Most exhausted T cells
Cure trial participation takes balance of risks and benefits
Interviews with 20 Australian people living with HIV have explored attitudes to clinical trial participation. Using guided interviews and hypothetical
Checkpoint blockade restores NK cell function
Does immune checkpoint blockade have indirect effects on cells other than CD4 T cells? Filippos Porichis and colleagues have studied
Sex hormone receptors regulate HIV latency
New research suggests that the estrogen receptor (ESR-1) is important in controlling HIV latency. In lab models of latent HIV
Antibody can act as a B cell blocker
Researchers have discovered a type of antibody that blocks normal immune responses in chronic HIV infection. NIH researchers studied blood
Engineered T cells stick around to reduce disease in monkeys
Designer T cells that attack HIV can trigger long-lived viral control in monkeys. Chimeric antigen receptor (CAR) T cells are
Compound shows potential to both ‘kick’ and ‘kill’ latent HIV
UCLA researchers have designed a new latency-reversing compound. SUW133 is similar to the known latency-reversing agent bryostatin and can both