Reversing latent HIV with mRNA and lipid nanoparticles: A promising new strategy
By Bridget Fisher and Dr Michael Moso Latent HIV that remains ‘silent’ in CD4 T cells is a major barrier […]
Latency reversing agents
Latent virus is virus that remains hidden, or ‘sleeping’ in the body during treatment. Latent virus does not make new copies of itself, making it effectively hidden from drug treatment. Latency reversing agents are drugs and other small molecules that ‘wake up’ this sleeping virus so that it can be targeted and removed from the body.
Reversing latency to cure HIV
HIV is a virus that inserts its own DNA into the host DNA upon infection. This “provirus” can remain dormant,
Managing hope and expectation: Perspectives on HIV cure
HIV cure. Those two little words elicit such hope, expectation and frustration. This was the theme that ran through the
HIV cure snapshot
The Australasian HIV&AIDS Conference (commonly known as ASHM after the organiser, the Australasian Society for HIV Medicine) was held online
Collaborations in cancer and HIV cure research
The HIV Cure & Cancer Forum brought cancer and HIV researchers together in Paris, as a prelude to the International AIDS
Reports of UK HIV cure are misleading
The international media have been at it again this week, with claims of an HIV cure thrown around in a
“Shock and kill” strategy reduces virus reservoir during treatment
Researchers have revealed the final results of the REDUC Part B clinical trial to reduce the HIV reservoir in a
Widely-used anti-alcoholism drug wakes up dormant HIV-infected cells
An Australian research team has found that disulfiram, a long-established and safe drug used primarily as a treatment for alcohol
HIV latency: a high-stakes game of hide and seek
The recent case of Scottish nurse Pauline Cafferkey, who relapsed nine months after “clearing” her Ebola infection, has raised concerns
HIV cure research: NIH scientists create two-headed protein to deplete HIV reservoir
WHAT: Scientists at the National Institutes of Health (NIH) have created a protein that awakens resting immune cells infected with
Combining PKC agonists and bromodomain inhibitors to reverse HIV latency
Two recent papers in PLoS Pathogens report that combinations of candidate latency-reversing agents can potently activate HIV production by latently
Cancer drug promises to break down barrier to HIV cure
Researchers have found a promising way of kicking the AIDS virus out of its hiding place in infected cells, potentially