Trust crucial to treatment interruption
At the Australasian HIV/AIDS Conference, Dr Gordon Campbell discussed participant motivations and experiences from an HIV cure clinical trial with treatment interruption (ATI). Dr Campbell interviewed...
Gene therapy advance in mice
A special session at the recent Australasian HIV/AIDS conference featured new research from the Kirby Institute. Dr Scott Ledger presented work on HIV gene therapy in mice. The results show blocking...
New sequencing method shows many blood-derived HIV particles are defective
Sydney researchers have developed a way to sequence near-full-length HIV-genomes from viral particles in the blood. This new test is called the PRLS (plasma-derived RNA using long-range sequencing)...
High CD4 count before HIV treatment contributes to smaller HIV reservoir on ART
Researchers found that people infected with HIV who maintained a CD4+ count during untreated infection as high as that in people not infected with HIV had a much smaller HIV reservoir after several...
Vitamin D3 affects the HIV reservoir in humans
Thirty PLHIV in Melbourne took part in the randomised, placebo-controlled VIVA trial. Researchers looked to see if 24 weeks of high dose vitamin D3 could reduce the amount of HIV that persists on ART....
Special delivery: nanoparticles to send latency-reversing drugs to lymph nodes
Latency-reversing agents (LRAs) are used to awaken, and possibly purge, the latent HIV reservoir. Two major challenges for LRA use in people are their toxic effect and difficulty getting into lymph...
CRISPR CCR5 edits safe but limited
Chinese scientists used CRISPR gene editing to alter CCR5 in stem cells from a 27 year old male. The edited cells were transplanted back into the man who was living with HIV and leukaemia. This was to...
HIV reservoir changes dramatically during prolonged ART
HIV integration into the host genome, forming the HIV reservoir, represents the major barrier to HIV eradication. It is not clear, however, how the HIV reservoir changes during long-term...
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