• About napwha
  • About this site
  • Contact Us
  • Subscribe
  • napwha website
HIV Cure

Find out about current studies

Get Involved
  • Home
  • Science
    • Reservoir, Remission, Rebound
    • Latency Reversing Agents
    • Gene Therapy
    • Vaccines
    • Novel Approaches
    • Research Spotlight
  • Clinical Trials
    • Get Involved
  • Community
  • Media
  • Video

Studies on three continents could have broad implications for HIV prevention research

3 years ago NAPWHA Vaccines
Share this:

Enrolment has begun in the first of two multinational clinical trials of an intravenously delivered investigational antibody for preventing HIV infection. Known as the AMP Studies, for antibody-mediated prevention, the trials will test whether giving people an investigational anti-HIV antibody called VRC01 as an intravenous infusion every 8 weeks is safe, tolerable and effective at preventing HIV infection.

With a projected enrolment of 4,200 adults, the trials also are designed to answer fundamental scientific questions for the fields of HIV prevention and vaccine research. The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), is sponsoring and funding the AMP Studies.

Read more here

antibody intravenous NIH vaccine

Previous Post

Search for the Holy Grail

Next Post

Antibody injections could be stepping stone to HIV vaccine

NAPWHA

NAPWHA

Founded in 1989, The National Association of People with HIV Australia (NAPWHA) is Australia’s peak non-government organisation representing community-based groups of people living with HIV (PLHIV).

How broadly neutralising antibodies...

1 year ago

Paris highlights

2 years ago

Seattle HIV conference showcases...

2 years ago

Reports of UK HIV...

2 years ago
  • RT @LTU_Sex_Health: Mark your calendars for this important community event @LTU_Sex_Health in collaboration with several organisations is h…
    March 1st, 2019
  • RT @pozmagazine: The Road Ahead for #HIV Cure Research https://t.co/awLonoKHFe
    March 1st, 2019
  • RT @LTU_Sex_Health: Mark your calendars for this important community event @LTU_Sex_Health in collaboration with several organisations is h…
    February 26th, 2019

New clue about HIV latency maintenance

Yale researchers have highlighted the role of APOBEC3A (A3A) in sustaining HIV latency. A3A is typically found in immune cells such as macrophages. The new study shows that A3A is also found in CD4 T cells. Detailed experiments in lab models of HIV latency show that A3A blocks HIV reactivation. A3A binds directly to HIV, then brings in other repressive proteins which alter the DNA structure. These epigenetic changes prevent HIV reactivation. If A3A is found to act in a similar way in HIV infected people, it could form a new target for reversing latency and progressing towards a cure.

What should a functional cure for HIV aim to do?

Combination strategy delays virus rebound in monkeys

New light on tricky HIV structure

Immune profiling tool to identify exhausted cells

  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2012

Supported by


Supported by the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health under Award Number U19AI096109. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

About NAPWHA

Founded in 1989, The National Association of People with HIV Australia (NAPWHA) is Australia’s peak non-government organisation representing community-based groups of people living with HIV (PLHIV).
Copyright (c) 2019. National Association of people with HIV Australia. ABN: 79 052 437 899


To help us understand who is reading our site, please let us know why you’re here: